The Inference Report

In neuropsychiatry, the primary goal is often not only to decode brain activity but to change it, for example to lessen a negative affective bias or an overly salient memory. Motivated by control theory, we develop an AI-driven neural-surrogate framework that proposes candidate representational changes and tests their predicted perceptual effects from snapshots of stimulus-evoked fMRI activity, without physical stimulation. The framework combines fMRI decoding, deep generative modeling, and constrained latent-space steering. Valence and memorability are used only as worked examples. Using more than 36,000 image-fMRI observations from four deeply sampled Natural Scenes Dataset participants, subject-specific models recovered coarse generative structure from visually responsive cortex (two-way identification, 0.79-0.88; chance, 0.5). Graded perturbations were reconstructed as images and evaluated with automated scorers and human ratings from 7,200 trials by 18 participants. In the primary VDVAE model, valence shifted from -0.61 to +1.03 SD and memorability from -1.34 to +1.45 SD; a later Versatile Diffusion refinement reduced or altered these effects. Across five perturbation levels, human valence ratings moved in the predicted direction under the linear time-correction model (mean slope, 0.038 SD per unit of alpha; 95 percent CI, 0.003-0.074; positive in 16 of 18 participants). Perceived memorability did not change reliably. Baseline agreement with the automated assessor was suggestive for valence (r = 0.30) and weak for memorability (r = 0.10). Extreme perturbations drifted from the original stimulus, so intended change must be weighed against loss of fidelity. These findings provide a falsifiable upstream method for designing and behaviorally testing candidate representational targets for future neuromodulation in psychiatry, while marking the limits of the present static approximation.

This article presents a mathematical model of the Motivated Emotional Mind cognitive architecture developed for embodied intelligent systems. Such a system learns to maintain its homeostasis through a generalized form of reinforcement learning based on its internal motivations, termed motivated learning (ML). The principal contribution of this article is a rigorous formalization of the re-entrant loop integrating feedforward processing, lateral interactions, and feedback pathways, together with the representational selection mechanisms that govern adaptive system responses. The model specifies how ongoing exteroceptive and interoceptive signals, bodily-motivational context, and memory traces are bound into associative memory structures termed semblions, which compete for access to further processing and top-down reconstruction. The formalization encompasses secondary perception, representational competition, curiosity, procedural gaps, and action selection directed toward limiting allostatic violations. Within this framework, motivated learning is tailored to embodied systems whose dynamics are shaped by needs, affect, and the current regulatory state. Unlike standard reinforcement-learning models, the proposed approach incorporates need thresholds, goal generation and shifting goals, bodily state, resource constraints, and action uncertainty, thereby providing a more adequate account of response selection under regulatory pressure. Global affect functions as a central control signal, modulating the learning rate, representational valence, and the balance between exploration and exploitation. The model presented here is a step toward a more rigorous formalization of cognitive phenomena and may provide a basis for further theoretical analysis, computer simulation, and implementation in artificial-intelligence systems inspired by biological processes.

We propose the Platonic brain bridge hypothesis: omni models, which process video, audio and text jointly like the brain, converge on brain-like representations, and the correspondence is bidirectional. From model to brain, brain-likeness of seven omni models is stable across participants, and our encoding models on their internal hidden states rank first on the Algonauts 2025 out-of-distribution leaderboard. From brain to model, three contributions follow. Brain-MoE gives seven cortical networks one brain-pretrained expert each and raises held-out accuracy in all 15 model-benchmark pairs by 6.42 percentage points on average. Brain-AVQA builds questions from video clips labelled by the most responsive brain network; the real network-to-expert map exceeds shuffled maps in-domain on all three models. Brain-Scope uses sparse autoencoders to localize the correspondence to a small subset whose removal weakens brain prediction in all three bases tested. Human brain networks are therefore a usable architectural prior for omni models.

Congruency effects, observed in conflict tasks such as Stroop and flanker tasks, have been investigated for nearly a century in psychology and neuroscience, but their mechanistic basis is not fully understood. We introduce a verbal-only LLM conflict task in which a prompt stem elicits a default same-color completion and an explicit rule either agrees with (congruent condition) or conflicts with (incongruent condition) the completion. Gemma-2-2B and six Pythia models ranging from 410M to 12B parameters showed strong default same-color tendencies, and six of seven models showed strong congruency effects. Using causal attribution analysis, attention analysis, and attention ablations, we identified distinct processing pathways in these LLMs: a pathway involving short-range attention to a superficial color cue that is preferentially activated in the congruent condition, and a pathway involving long-range attention to the rule prefix that is preferentially activated in the incongruent condition. Fine-tuning that strengthened the default same-color tendency had divergent effects on task conditions, reducing incongruent performance while increasing congruent performance. In contrast, increasing rule set size selectively impaired incongruent performance. These converging findings support an account in which congruency effects in this task arise from competition between an in-weight default mapping and an in-context rule-based mapping. More broadly, our findings illustrate how LLMs can serve as model systems for mechanistic analysis of competition between default and rule-governed response tendencies within a single learned network.

Identifying individual learning styles optimizes pedagogical efficacy. While traditional questionnaires are structured, behavioral tracking methods require prolonged interaction log accumulation. To overcome these temporal constraints, this paper proposes an objective Electroencephalography (EEG) approach evaluating Phase Locking Value (PLV) connectivity against localized features across the Active-Reflective (AR) and Verbal-Visual (VV) Felder-Silverman dimensions. EEG signals were recorded from 28 participants during Raven's Advanced Progressive Matrices tasks. Support Vector Machine classification used Leave-One-Subject-Out Cross-Validation (LOSO-CV) alongside a 70:30 intra-subject split. The VV dimension achieved 70.00% subject-level accuracy driven by distinct fronto-occipital polarization. Conversely, the AR dimension yielded lower cross-subject generalizability (55.56%) due to overlapping executive networks and a "Systematic Neural Inversion" phenomenon, where stable individual connectivity signatures operated diametrically opposed to global boundaries (up to 20-0 voting margins). Ultimately, these outcomes demonstrate that rigid "one-size-fits-all" classifiers are bounded by biological diversity, emphasizing the need for future adaptive feature transformation techniques to bridge the cross-subject generalization gap.

The life sciences and health research have started to benefit from artificial intelligence, which raises ethical concerns that are real but, we argue, not special. Any science should be governed by values that rest on how the human brain is built and socialised rather than anything distinct to artificial intelligence. Importantly, the human brain has a different, much less costly computational architecture than these machines. This is achieved through the orchestration of a global neuronal workspace, and through reward best described not as a quantity to be maximised but as a continuous cycle of wanting, liking and satiety. As such, this creates the deep tension running through the ethics of the human person, between the universality of ethical judgement and the diversity of morals. The brain networks of the global workspace and emotion are universally shared, but the diversity of content is shaped by epigenetic appropriation of the particulars of the physical, social and cultural world, which makes every person unique. Still, if we were to build machines on these principles rather than the present unaffordable reward maximisers, the question of their governance would change from restraint to upbringing. We set out the institutions such a future would require, together with the questions that remain open.