The Inference Report

May 7, 2026

The infrastructure that powers AI is consolidating around a utility layer that will outlast any particular model or lab. Like the railroad barons of the nineteenth century who profited more from controlling tracks than from operating trains, today's winners are companies managing compute, data centers, and distribution channels rather than publishing breakthrough papers. Anthropic rents capacity from xAI, which is building a $119 billion chip factory in Texas. TSMC backs renewables to handle the energy crunch. Samsung crossed $1 trillion in valuation on chip demand alone. Arm projects $2 billion in AI chip sales from next year. The actual AI companies have become tenants in someone else's infrastructure play, and this shift is accelerating faster than model capability improvements. Meanwhile, regulatory capture is being dressed up as safety oversight. Trump's endorsement of AI testing, combined with the Center for AI Standards and Innovation signing pre-deployment evaluation agreements with Google DeepMind, Microsoft, and xAI, creates a system where incumbents vet their own competitors before launch. The threat is DeepSeek's $45 billion valuation, built on models trained at a fraction of US compute costs, which makes government gatekeeping suddenly appealing to the labs that shaped this moment. The real story beneath the safety rhetoric is ownership of the upside: Greg Brockman's stake worth $30 billion, Shivon Zilis's testimony about Musk recruiting Altman, the public history of the lawsuit all reveal that the fight is over who owns the technology when it works.

The labs are no longer competing primarily on model capability. Every one is racing to own a piece of the path from model to production, and whoever controls the most friction points wins customer lock-in. OpenAI stacks use cases with Uber and Singular Bank to show that AI adoption compounds into competitive moat. AWS and GitHub are releasing MCP servers and validation frameworks that lock customers into their platforms. NVIDIA and OpenAI's joint push around Multipath Reliable Connection through the Open Compute Project, paired with NVIDIA's Spectrum-X Ethernet fabric and Corning's optical manufacturing partnership, signals that whoever controls the physical layer controls the economic rents. The agent infrastructure layer is crystallizing around stateful, long-running systems that coordinate multiple specialized sub-agents. Repos like deer-flow and ruflo handle multi-agent coordination, memory management, and tool integration. Domain-specific agents built on that infrastructure handle financial research, retrieval, and data persistence. The single-turn LLM call is no longer the unit of work. Distribution is fragmenting too. The Snap-Perplexity deal fell through amicably, revealing that Perplexity did not need Snap's users enough to surrender equity or control. Google adds Reddit quotes to search. Ethos onboards 35,000 experts per week through voice. The assumption that one platform would own the entire value chain is breaking down. The winners will control either the compute or the users. Everyone else is renting.

Grant Calloway

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From the WireAll feeds
Research Papers — FocusedAll papers
Physics-Guided Multi-Objective Deep Learning for Ultrasound RF Data Interpolation in Resource-Constrained Imaging eess.IV

Ultrasound imaging increasingly targets portable, point-of-care, and wearable settings where constraints on power, bandwidth, and hardware complexity often necessitate sparse data acquisition in spatiotemporal scanning. However, image reconstruction using the sparse data can introduce insufficient phase information in coherent beamforming process, resulting in grating-lobe artifacts that degrade imaging contrast resolution. We present a physics-guided, data-driven framework for sparse-to-dense radio-frequency (RF) reconstruction that aligns training with downstream image formation. Our approach trains an end-to-end interpolation network using a hybrid supervision scheme that combines an RF-domain and a beamforming-domain loss with exponential moving average (EMA) to stabilize the multi-objective training. To improve generalization under variable acquisition layouts, we also introduce a random-skip masking strategy that varies sparsity patterns during training so a single model can handle diverse decimation factors and irregular channel configurations. We evaluate the framework on a held-out test set using the mean structural similarity index measure (SSIM) between reconstructed and ground-truth beamformed images. Across decimation factors $\times 2$ to $\times 13$, the best-performing configuration maintains mean SSIM around 0.95. Overall, the results show consistent gains in RF reconstruction and post-beamforming image quality across diverse acquisition conditions. This approach enables robust, high-quality ultrasound imaging at resource-constrained settings by allowing more sparse scanning in spatiotemporal domain.

Learning-Based 3D Reconstruction of Power Networks from Aerial Point Clouds eess.IV

This paper presents an end-to-end framework for reconstructing overhead power utility network topology and extracting span-level physical metadata from large-scale aerial LiDAR. The pipeline begins with semantic segmentation of the input point cloud using an improved KPConv-based model, in which data sampling and loss functions are adapted to emphasize pole and conductor (wire) classes. Network topology inference then proceeds in two stages: (i) pole instances are obtained by clustering pole-class points and validating candidates using geometric criteria, including height and verticality estimated via PCA, and (ii) candidate pole pairs are evaluated using a heuristic method and a lightweight ResNet-based classifier on 2D top-view projections of pole and wire point distributions to determine whether a physical conductor span exists. By explicitly classifying candidate spans, the approach mitigates common failure modes of heuristic connectivity rules in dense or cluttered scenes and under partial wire observation. For each validated wire, attributes regarding utility infrastructure geometry are computed, including endpoint conductor heights, ground elevation, sag-related lowest-point features, conductor arrangement, and wire width. Evaluation on multiple real-world aerial LiDAR datasets demonstrates decimeter-level endpoint height accuracy and approximately 9% relative improvement in recall for topology reconstruction compared to heuristic nearest-neighbor baselines, with larger gains in complex layouts.

ORION-CMR: On-scanner Reporting with Integrated Foundation Model for End-to-End Cardiac MRI Analysis and Interpretation eess.IV

Cardiovascular magnetic resonance (CMR) provides comprehensive cardiac assessment but remains underutilized because of the complexity of acquisition, post-processing, and interpretation. Existing artificial intelligence (AI) methods address isolated tasks, limiting clinical integration. We present ORION-CMR (On-scanner Reporting with Integrated fOunda-tioN Model), the first clinically evaluated scanner-native end-to-end CMR foundation model. Pretrained on 12,896,733 CMR images from 9,258 studies, ORION-CMR performs sequence classification, ventricular function assessment, late gadolinium enhancement (LGE) detection, binary and multiclass disease classification, and local large language model-based report generation in approximately 90 seconds. The framework. was evaluated on public benchmarks and clinically validated in a multi-vendor cohort of 68 subjects with normal examinations, congenital heart disease, dilated cardiomyopathy, and myocardial infarction. ORION-CMR outperformed supervised baselines and the previously published CMR foundation model (CMR-FM), achieving state-of-the-art performance for LGE classification and scar segmentation. Clinical evaluation achieved an AUC of 0.96 for normal-versus abnormal classification and 0.88 for multiclass disease classification, while generated reports demonstrated 81.4% agreement with expert interpretation. These results demonstrate the feasibility of real-time scanner-native AI-assisted CMR analysis and automated report generation.

Perceptual Refinement of an End-to-End Video Streaming Pipeline via Generative AI Layers eess.IV

Traditional codecs treat every region of a frame alike; a generative layer can instead degrade the regions a viewer attends to least and reconstruct them at the client. We present PRESLEY, which extends the prior conference work ELVIS by replacing destructive block removal with adaptive in-place degradation under a removability mask, signaling per-block strength in a bit-packed side channel, and restoring via generative backbones conditioned on transmitted visual priors rather than unconditioned in-painting. We separate the problem into three goals: choosing which blocks to degrade, degrading them so the encoder spends fewer bits, and restoring them. Against its predecessor at matched rate, PRESLEY achieves a decisive mean -56.4% BD-rate reduction on delivered background quality across 13 rate ladders spanning multiple codecs and dataset families. Against pristine baselines, PRESLEY defines the operating regime of generative transport: delivering substantial bitrate savings (up to -29.4% BD-rate) and superior background quality (17/23 sequences) in the target bit-starved regime, while maintaining foreground fidelity bit-exact. We further map where the theoretical headroom in this class of architecture lies. Using an exact leave-one-superblock-out combinatorial oracle as an additive empirical bound, we show that existing complexity heuristics already capture 83.3% of bit-cost savings, bounding remaining cost-axis headroom at about 5% of total bitrate. We then identify and model the primary unaddressed axis -- post-restoration damage -- which disperses widely (4.9-8.4 dB). We prove that this damage is predictable before transmission (held-out rho = +0.400), establishing the feasibility of transmit-time restorability modeling and defining the roadmap for joint rate-distortion-restoration selection rules.

Physics-Informed Hemodynamic Modeling for Data-Free Prediction and Sparse-Data Assimilation eess.IV

Clinical decision-making for coronary intervention relies mainly on angiography and fractional flow reserve (FFR). However, angiography is two-dimensional and lacks depth information for 3D lesion characterization, while FFR provides only a single functional index, offering limited hemodynamic insight. Among existing methods, numerical analysis is computationally expensive, whereas learning-based approaches require extensive supervision and often lack physical consistency. To address these limitations, we propose physics-informed hemodynamic modeling, an integrated deep learning framework for 3D coronary blood flow analysis from dual-view angiography. First, an attention-enhanced CNN reconstructs coronary geometry from angiography. The resulting point clouds are then mapped to a reference domain and Fourier-encoded for joint representation. A decoupled network separately predicts velocity and pressure fields, with embedded physical priors enabling efficient transfer across physiological conditions. Across 32 clinical patients evaluated under four flow conditions, the trans-stenotic pressure-drop mean absolute percentage error was 2.02%, while the velocity and pressure relative-L2 errors were 0.054 and 0.023, respectively. Validation against hospital-measured FFR further achieved 93.8% diagnostic accuracy (30/32; exact 95% CI, 79.2%-99.2%). The framework also supports illustrative revascularization comparisons and sparse-data assimilation, with the full angiography-to-hemodynamics pipeline completed within 20 minutes per patient.

Mammography Foundation Models for Opportunistic Prediction of Major Adverse Cardiovascular Events eess.IV

Cardiovascular disease (CVD) remains the leading cause of death among women, yet cardiovascular risk assessment often relies on clinical variables that may be missing, outdated, or unavailable in routine care. Screening mammography offers an opportunity for opportunistic cardiovascular risk stratification because it is routinely acquired and contains vascular features, including breast arterial calcifications (BAC), that are associated with cardiovascular risk and events. We evaluate whether mammography specific foundation models, originally pretrained for breast cancer-related tasks, can transfer to cardiovascular risk prediction without cardiovascular specific supervision or explicit BAC annotation. We constructed a 5-year major adverse cardiovascular event (MACE) cohort of 22,497 women linked to electronic health record outcomes, including 500 events (2.22% prevalence). The foundation models achieved AUROCs of 0.823 and 0.822 substantially exceeding an age-only model (AUROC 0.765), despite using only the screening mammogram as input, with no clinical variables. Both foundation models evaluated assigned substantially higher predicted risk to patients with radiologist-documented BAC, despite BAC never being used as a training label, and showed activation patterns consistent with vascular findings. Together, these findings suggest that mammography foundation models can recover clinically relevant cardiovascular risk information directly from mammographic pixels and suggest that screening mammography may provide an opportunistic source of cardiovascular risk information to complement conventional clinical assessment without additional imaging. Code is available in https://github.com/PauFeld/MammoCVD

BenchmarksFull tables
Artificial AnalysisIntelligence Index

Composite score across coding, math, and reasoning

#ModelScoretok/s$/1M
1GPT-5.560.279$11.25
2Claude Opus 4.757.362$10.94
3Gemini 3.1 Pro Preview57.2131$4.50
4GPT-5.456.880$5.63
5Kimi K2.653.928$1.71
SWE-rebench

Agentic coding on real-world software engineering tasks

#ModelScore
1Claude Opus 4.665.3%
2gpt-5.2-2025-12-11-medium64.4%
3GLM-562.8%
4Junie62.8%
5gpt-5.4-2026-03-05-medium62.8%